Results 101 to 110 of about 519,891 (291)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Designing Improved Sediment Transport Visualizations [PDF]

open access: yes, 2013
Monitoring, or more commonly, modeling of sediment transport in the coastal environment is a critical task with relevance to coastline stability, beach erosion, tracking environmental contaminants, and safety of navigation.
Beaudoin, Jonathan   +6 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

WISP information display system user's manual [PDF]

open access: yes
The wind shears program (WISP) supports the collection of data on magnetic tape for permanent storage or analysis. The document structure provides: (1) the hardware and software configuration required to execute the WISP system and start up procedure ...
Alley, P. L., Smith, G. R.
core   +1 more source

Test results of the DOE/Sandia 17 meter VAWT [PDF]

open access: yes, 1979
A review is given of the test program of a 17 meter Vertical Axis Wind Turbine VAWT. Performance test results are discussed including difficulties encountered during the VAWT operation along with ways of solving these ...
Nellums, R. O., Worstell, M. H.
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu   +11 more
wiley   +1 more source

SPECTRASAT: A concept for the collection of global directional wave spectra [PDF]

open access: yes, 1984
The synthetic aperture radar (SAR) imagery from SEASAT revealed a rich tapestry of backscatter patterns from the surface of the ocean. Although still far from being fully understood, these patterns occurred on nearly all spatial scales accessible to the ...
Beal, R. C.
core   +1 more source

Retrofit of a Resilient Hybrid Power System for a Remote Island

open access: yesChemical Engineering Transactions, 2015
A mathematical model is presented for the synthesis and retrofit of a resilient electricity network for a remote island. The current electricity network uses diesel fuel power plant as the main power source and will be supplemented with wind turbines in ...
C.-L. Chen, H.-C. Chen, J.-Y. Lee
doaj   +1 more source

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