Results 91 to 100 of about 423,278 (362)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
DEVELOPMENT OF RENEWABLE ENERGY IN UKRAINE, CURRENT STATE AND POSSIBLE SOLUTIONS [PDF]
Sustainable Extraction and Processing of Raw Materials Journal. The article analyses the current state and prospects of using renewable energy sources in Ukraine and across the world. The list and current state of wind power plants in Ukraine and the impact of military operations on them are presented.
Olha Medvedieva +2 more
doaj +1 more source
Wind power integration into the automatic generation control of power systems with large-scale wind power [PDF]
, 2014 Transmission system operators have an increased interest in the active participation of wind power plants (WPP) in the power balance control of power systems with large wind power penetration. The emphasis in this study is on the integration of WPPs into
Altin, Müfit +4 more
core +2 more sources
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Оценка целесообразности использования концентраторов воздушного потока в ветроэнергетических установках [PDF]
, 2011 The proposed numerical method for calculating wind turbine power plants with a concentrator of air flow.
Калкаманов, С. А. +2 more
core
A Review on Wind Speed Extreme Values Modeling and Bayes Estimation for Wind Power Plant Design and Construction [PDF]
, 2023 E. Chiodo +3 more
openalex +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
IEEE Access, 2019 With the increasing need for the energy, the importance of renewable energy sources has also been increasing. In order to include the power produced by the wind into electricity grid in a controlled manner, power prediction has an important role.
Mehmet Baris Ozkan, Pinar Karagoz
doaj +1 more source