Results 51 to 60 of about 3,243,628 (360)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Analysis of Wind Speed Characteristics Along a High-Speed Railway

Applied Sciences
The safe operation of high-speed railways (HSRs) is significantly challenged by strong winds. Accurate wind speed prediction along HSRs is crucial for ensuring the safety of train operations.
Xin Chen, Xiaoling Ye, Yingchao Zhang, Xiong Xiong   +3 more
doaj   +1 more source

Design of automatic control system of circular low speed wind tunnel and its measurement uncertainty evaluatio

Gong-kuang zidonghua, 2017
In order to satisfy demands of rapid, accurate, automatic detection of mine-used wind speed sensor and wind speed impact test of mine-used gas sensor, an automatic control system of circular low speed wind tunnel was designed. The system uses PLC as main
CHU Weizhong
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Wind characteristics near ground in south-eastern coast area of China based on field measurement

Geomatics, Natural Hazards & Risk, 2016
From the point of view of wind engineering, this paper discusses the wind characteristics of China's south-eastern coast area near the ground based on field measurements.
Bo Li, Qingshan Yang, Jingbo Yang
doaj   +1 more source

Assessment of onshore wind energy potential under temperate continental climate conditions

Energy Reports, 2022
Using the Weibull distribution function, the study presents a statistical evaluation of wind characteristics and onshore wind power potential under temperate continental climate conditions.
Spiru Paraschiv, Lizica Simona Paraschiv, Alexandru Serban, Anisoara Gabriela Cristea   +3 more
doaj   +1 more source

Shrouded wind turbine for low wind speed

IOP Conference Series: Materials Science and Engineering, 2021
Abstract The problem of electrification in Indonesia for remote areas is difficult to access and far away from the grid of PLN, so an alternative is needed to overcome this problem. One alternative to this problem is to build off-grid power plants by utilizing natural potential in an area such as wind energy, but not all regions have ...
Muhammad Nasrul, Illa Rizianiza
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source