Results 61 to 70 of about 426,887 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

On the varying slope of velocity spectra [PDF]

open access: yes, 1986
Spectra of zonal, meridional and vertical wind velocity, measured during a 24 hour period with the spaced-antenna technique indicate quite a variable slope as a function of height.
Rottger, J.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Aerodynamic noise evaluation for Aeolian tone and acoustical insulating plate by similarity law

open access: yesMechanical Engineering Journal, 2020
The objective of this research is to assess aerodynamic noise sources and the wind velocity conversion of the similarity law in an increasing wind velocity.
Akitoshi MATSUI   +2 more
doaj   +1 more source

Measuring Surface Wind Velocity Changes

open access: yes2015 ASABE International Meeting, 2015
Abstract. Agricultural spray drift is affected by many factors ranging from current weather conditions and the topography of the surrounding area, to the properties at the nozzle and the height at which the spray is released. Wind direction, speed, and solar radiation during the late spring/summer spray season of 2014 was measured at 10 Hz ...
Schramm, Matthew   +4 more
openaire   +3 more sources

Neutron star masses from hydrodynamical effects in obscured sgHMXBs

open access: yes, 2012
A population of obscured supergiant High Mass X-ray Binaries (sgHMXBs) has been discovered by INTEGRAL. X-ray wind tomography of IGR J17252-3616 inferred a slow wind velocity to account for the enhanced obscuration.
Blondin, J. M.   +2 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Quasi-Periodic Releases of Streamer Blobs and Velocity Variability of the Slow Solar Wind near the Sun

open access: yes, 2009
We search for persistent and quasi-periodic release events of streamer blobs during 2007 with the Large Angle Spectrometric Coronagraph on the \textit{Solar and Heliospheric Observatory} and assess the velocity of the slow solar wind along the plasma ...
A.B. Galvin   +27 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

PREDICTION OF POWER GENERATION OF SMALL SCALE VERTICAL AXIS WIND TURBINE USING FUZZY LOGIC

open access: yesJournal of Urban and Environmental Engineering, 2009
Renewable energy from the wind turbine has been focused for the alternative source of power generation due to the following advances of the of the wind turbine. Firstly, the wind turbine is highly efficient and eco-friendly. Secondly, the turbine has the
Altab Md. Hossain   +4 more
doaj   +1 more source

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