Results 131 to 140 of about 193,173 (339)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Digital memory in which the driving of each word location is controlled by a switch core Patent [PDF]
, 1969 Digital memory system with multiple switch cores for driving each word ...
Zottarelli, L. J.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Non-contacting power transfer device [PDF]
, 1982 A transformer for coupling AC electrical energy from a stationary element to a rotating element without the use of sliding contacts is described. The transformer is of the rotary type and includes a ferrite core and two primary windings which are ...
Paulkovich, J., Studer, P. A.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
AIP AdvancesIn this article, the new three-phase U-shaped and V-shaped consequent-pole hybrid excited machines with separated windings (CHEPMS machine) are proposed for superconducting flywheel energy storage. The stator teeth are divided into two types.
Guangyu Qu +4 more
doaj +1 more source
Solid-State Transformers for Interfacing Solar Panels to the Power Grid: An Optimum Design Methodology of a High Frequency Transformer for dc-dc Converter Applications [PDF]
, 2016 Nowadays the use of power electronic interfaces to integrate distributed generation with the power grid is becoming relevant due to the increased penetration of renewable energy sources like solar, and the continued ...
George, Kenny
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source