Results 151 to 160 of about 193,173 (339)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Algorithmic Design of Modular Two-Layer Multiphase Windings Based on Number Theory
EnergiesMany electromechanical specialists have attempted to move away from the classical method of designing windings of electrical machines using the star of slot electromotive forces, but their approaches are not always simple or universal.
Bohdan Kharchyshyn +4 more
doaj +1 more source
Development of a renewable hybrid power plant with extended utilization of pumped storage unit equipment [PDF]
, 2019 The scheme of a renewable hybrid power plant with the extended use of the installed equipment of the pumped storage unit for the conversion of the photovoltaic and wind generators direct current to the alternating one is proposed.
Chervonenko, I. +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Identification System for Short-Circuit Fault Points in Concentrated Stator Windings of Motors
EnergiesMotors serve as the primary power sources in a wide range of industrial fields. In recent years, their application has been expanded to electric and hybrid electric vehicles.
Hisahide Nakamura, Yukio Mizuno
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Wind analysis for wind power: Part III
MAUSAM, 1981 The paper contains frequency distribution of hourly values of winds of Jamnagar in north Saurashtra in the four ranges, viz., light, moderate, strong and very strong with the objective of utilization of energy from winds for the wind mills. Monthwise frequency distribution is also presented.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source