Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Investigations on the performances of the electrical generator of a rim-driven marine current turbine” [PDF]
, 2014 In this paper, the electrical generator of a rim-driven horizontal-axis current turbine is modeled in detail. Its main characteristics and performances are evaluated (efficiency, mass, cost, etc).
CHARPENTIER, Jean-Frederic +3 more
core +1 more source
Line-start permanent-magnet motor single-phase steady-state performance analysis [PDF]
, 2003 This paper describes an efficient calculating procedure for the steady-state operation of a single-phase line-start capacitor-run permanent-magnet motor.
Cossar, C. +6 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Digital memory in which the driving of each word location is controlled by a switch core Patent [PDF]
, 1969 Digital memory system with multiple switch cores for driving each word ...
Zottarelli, L. J.
core +1 more source
Supersymmetry breaking, open strings and M-theory [PDF]
, 1998 We study supersymmetry breaking by Scherk-Schwarz compactifications in type I string theory. While in the gravitational sector all mass splittings are proportional to a (large) compactification radius, supersymmetry remains unbroken for the massless ...
Antoniadis, I., Dudas, E., Sagnotti, A.
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Variable frequency magnetic multivibrator Patent [PDF]
, 1964 Variable frequency magnetic coupled multivibrator with temperature compensated frequency control ...
Paull, S.
core +1 more source
Iron Losses Prediction with PWM Supply Using Low and High Frequency Measurements: Analysis and Results Comparison [PDF]
, 2008 In this paper, two different methods for iron loss prediction are analyzed. The first method is based on the classical separation of loss contributions (hysteresis, eddy-current, and excess losses).
Boglietti, Aldo +2 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source