Results 61 to 70 of about 1,413,465 (300)

Investigation of Thermal Bridges of a New High-Performance Window Installation Using 2-D and 3-D Methodology

Buildings, 2022
The investigation of building elements regarding energy saving is a paramount issue, with EU Directives driving achievement goals, focusing on buildings’ energy performance and energy efficiency.
Jolanta Šadauskienė, Juozas Ramanauskas, Dorota Anna Krawczyk, Eglė Klumbytė, Paris A. Fokaides   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The 'Window' Terminal [PDF]

The Computer Journal, 1987
A program ROM has been developed for the BBC microcomputer, which makes it function as a powerful window management terminal, with a high resolution display, mouse and programmable keyboard. The BBC Window terminal ROM provides a cheap alternative to the more expensive windowing workstations that provide the same resolution and facilities.
J. Parker, A. Kennard, D. King
openaire   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The View from the Window—Assessment by the “View Owner” and the “View Observers”

Buildings
Access to an unobstructed view of the outside through a window has been shown to play a critical role in supporting occupants’ visual comfort, psychological well-being, and cognitive performance, as it provides environmental connection and reduces stress.
Barbara Szybinska Matusiak, Mandana Sarey Khanie, Natalia Sokol, Aicha Diakite-Kortlever, Valerio Roberto Maria Lo Verso, Laura Bellia, Francesca Fragliasso, Melissa Mittelstädt   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

In Situ Thermal Performance Assessment of a Wood–Aluminum Window: Case Study of Spatial Variability, Dynamic Effects, and U-Value Accuracy

Buildings
This paper presents an experimental evaluation of the thermal performance of a wood–aluminum window installed in a timber building exposed to real climatic conditions. The assessment is based on long-term in situ measurements of heat flux and temperature
Rastislav Igaz, Patrik Štompf, Martin Čulík   +2 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source