Results 191 to 200 of about 435,383 (315)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A European monsoon-like climate in a warmhouse world. [PDF]

Nat Commun
Van Horebeek N, de Winter NJ, Baatsen M, Ziegler M, Speijer RP, Vellekoop J.   +5 more
europepmc   +1 more source

Two-Stage Stochastic Scheduling of Cascaded Hydropower–Wind–Photovoltaic Hybrid Systems Considering Contract Decomposition and Spot Market [PDF]

Yang Li, Ni Fang, Shengming He, Feng Wu, Outing Li, Linjun Shi, Renshan Ding   +6 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Stratified wind from a super-Eddington X-ray binary is slower than expected. [PDF]

Nature
XRISM collaboration.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Impact of atmospheric rivers on coastal oceanographic conditions off central-southern Chile. [PDF]

Sci Rep
Garcia-Santos Y, Narváez DA, Saldías GS, Jacques-Coper M, Bozkurt D, Garreaud R, Valdés-Castro V.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Flight performance of great cormorants Phalacrocorax carbo sinensis suggests sufficient muscle capacity for adaptive speed adjustment. [PDF]

J Exp Biol
Hedenström A, KleinHeerenbrink M, Åkesson S.   +2 more
europepmc   +1 more source

Qualitative Investigation of Wake Composition in Offshore Wind Turbines: A Combined Computational and Statistical Analysis of Inner and Outer Blade Sections [PDF]

M. Salman Siddiqui, Abdul Waheed Badar, Liang Yang, Muhammad Saeed, Arvind Keprate   +4 more
openalex   +1 more source