Results 221 to 230 of about 1,598,590 (349)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Tropical volcanism triggers pan-Asian monsoon droughts via circumglobal teleconnection. [PDF]

Nat Commun
Nie W, Xia J, Kino K, She D, Oki T.
europepmc   +1 more source

Rapid subsurface warming and circulation changes of Antarctic coastal waters by poleward shifting winds

, 2014
P. Spence, S. Griffies, M. England, A. Hogg, O. Saenko, N. Jourdain   +5 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

WHACS: An Improved Global Wave Hindcast for the Australian Climate Service. [PDF]

Sci Data
Smith G, Meucci A, Spillman C, Hoeke R, Hernaman V, Trenham C, Zieger S, Hally B, Echevarria E.   +8 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The risk of hospitalization associated with foehn winds and temperature in the mountainous region of Switzerland. [PDF]

Environ Epidemiol
Schneidewind T, Lee S, Vicedo-Cabrera AM, Saucy A.   +3 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Southern Ocean seabird population shifts over the Holocene revealed by peat sequestration of mercury from guano. [PDF]

Proc Natl Acad Sci U S A
Li C, Roberts SJ, Grosjean M, Mestrot A, Wille M, Phillips RA, Enrico M, Bishop K, Skyllberg U, Mauquoy D, von Scheffer C, Theurer T, Muirhead D, Whittle A, Gallego-Sala A, Sonke JE, De Vleeschouwer F, Van der Putten N, Braconnot P, Marti O, Osterwalder S, Buchmann N, Frölicher T, Anthamatten E, Chiaia-Hernández AC, Zahajská P, Jeandel C, Saunders KM, Kwon SY, Wang D, Bindler R, Sime L, Hodgson DA.   +32 more
europepmc   +1 more source