Results 51 to 60 of about 435,383 (315)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

First Studies of Mesosphere and Lower Thermosphere Dynamics Using a Multistatic Specular Meteor Radar Network Over Southern Patagonia

Earth and Space Science, 2021
This paper presents for the first time results on winds, tides, gradients of horizontal winds, and momentum fluxes at mesosphere and lower thermosphere altitudes over southern Patagonia, one of the most dynamically active regions in the world.
J. Federico Conte, Jorge L. Chau, Juan M. Urco, Ralph Latteck, Juha Vierinen, Jacobo O. Salvador   +5 more
doaj   +1 more source

Magnetically advected winds [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2017
Abstract Observations of X-ray absorption lines in magnetically driven disc winds around black hole binaries and active galactic nuclei yield a universal radial density profile ρ ∝ r−1.2 in the wind. This is in disagreement with the standard Blandford and Payne profile ρBP ∝ r−1.5 expected when the magnetic field is neither advected nor ...
Contopoulos, Ioannis, Kazanas, Demosthenes, Fukumura, Keigo   +2 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Observational evidence of the relationship between the tropical tropopause and tropical easterly jet streams over the Indian monsoon region

Atmospheric Science Letters
This paper presents the first quantitative relationship between the cold point tropopause (CPT) and tropical easterly jet (TEJ) using radiosonde observations over Gadanki (13.45° N, 79.2° E) during the Indian summer monsoon season 2006–2014.
Sanjay Kumar Mehta
doaj   +1 more source

Mass Transfer in Mira-Type Binaries

Open Astronomy, 2012
Detached, symbiotic binaries are generally assumed to interact via Bondi-Hoyle-Littleton (BHL) wind accretion. However, the accretion rates and outflow geometries that result from this mass-transfer mechanism cannot adequately explain the observations of
Mohamed S., Podsiadlowski Ph.
doaj   +1 more source