Results 161 to 170 of about 450,371 (196)

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Digital Transformation: Are Traditional Auditors' Competencies Sufficient for Remote ISO 14001 Audits?

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This article explores how practitioners perceive the effects of digital transformation on ISO 14001 audits and on the competencies required to conduct them remotely. The study draws on 35 semi‐structured interviews with representatives of ISO‐14001‐certified organizations, external auditors, and consultants. While few studies have examined the
Nadjet Tebbal, Olivier Boiral, Alexander Yuriev   +2 more
wiley   +1 more source

Uniaxial compressive strength prediction and ratio parameter optimization of titanium tailings composite backfill materials using intelligent hybrid models

Deep Underground Science and Engineering, EarlyView.
Based on the 90 datasets, ERT and four optimization algorithms were used to build four hybrid models to predict the UCS of the backfill body. The SMA‐ERT model was the most effective model, and it can reliably guide the design of the backfill ratio parameters. Abstract This study analyzed the feasibility of using titanium (Ti) tailings as a backfilling
Weijun Liu, Zida Liu, Zhixiang Liu
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Climatic thresholds and temporal decoupling drive reproductive phenology in Neotropical cloud forests: a 36‐year analysis

Ecography, EarlyView.
Reproductive phenology influences ecosystem functioning and climate sensitivity in tropical montane cloud forests, but phase‑specific climatic thresholds and the temporal coupling between flowering and fruiting remain poorly quantified over decadal scales. We analyzed a 36‑year monthly record (1983–2018) from a Venezuelan cloud forest (15 focal species)
Saúl Flores, Nuriangel Casanova‐Hernández, Hendrik Sulbaran‐Pineda   +2 more
wiley   +1 more source

Flexible Direct‐Conversion X‐Ray Detectors: From Emerging Materials to Conformal Imaging

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This comprehensive review analyzed the performance, challenges, and future directions of four emerging material systems for next‐generation flexible direct‐conversion X‐ray detectors: organic semiconductors, perovskites, metal–organic frameworks, and inorganic metal compounds.
Haipeng Di, Guoliang Ma, Jiaxin Mu, Kailian Dong, Haibin Li, Manjing Wang, Xin Song, Haojin Li, Jianwei Xu, Yiying Zhao, Jingjing Zhao, Guojia Fang   +11 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Magneto‐responsive fibers and fabrics for soft systems

FlexMat, EarlyView.
Abstract The combination of functional materials in fiber form has led to a surge in the integration of functional fibers and fabrics into soft systems that span sensing, communication, and actuation domains. A key subset is magnetic fibers and fabrics.
Hanlin Zhu, Jingxian Cui, Qingchao Fan, Zefeng Zhang, Chao Jiang, Hwa‐Yaw Tam, Yan Zhao, Zhe Wang, Zhixun Wang   +8 more
wiley   +1 more source

Recent advances in chiral organic room‐temperature phosphorescence with circularly polarized luminescence

FlexMat, EarlyView.
This review systematically summarizes representative recent advances in organic circularly polarized room‐temperature phosphorescence materials toward optoelectronic and information security applications. Abstract Circularly polarized room‐temperature phosphorescence (CPRTP) materials combine the dual advantages of long‐lived triplet emission and ...
Liang Zhang, Ming‐Jun Ji, Chuan‐Feng Chen   +2 more
wiley   +1 more source

Guidelines for Immunomodulatory Assays of Food Bioactives on Drosophila melanogaster Model

Future Postharvest and Food, EarlyView.
Guidelines are proposed for evaluating the immunomodulatory effects of food bioactives in Drosophila melanogaster, involving treatment with bioactives, pathogen preparation, infection routes, and immune response assessment. This model highlights the conserved mechanisms of cellular and humoral immunity for studying host‐microbe interactions.
Wenqi Huang, Shiye Lin
wiley   +1 more source