Results 221 to 230 of about 6,439,138 (286)

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang   +5 more
wiley   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang   +3 more
wiley   +1 more source

Nanoscale Rear‐Interface Architecture Enables 36.2 mA cm−2 Photocurrent in Ultrathin and Bifacial ACIGS Solar Cells Through Light Management

open access: yesLaser &Photonics Reviews, EarlyView.
An array of SiOx nanopillars is developed on ITO transparent rear contacts through nanoimprint lithography to promote light scattering in 500–600 nm bifacial ACIGS solar cells. This architecture increases the short‐circuit current density by 7.8 and 7.6 mA cm−2 under front (up to 36.2 mA cm−2) and rear illumination, respectively, offering a scalable ...
Enzo J. Ribeiro   +11 more
wiley   +1 more source

Tackling saiga horn consumption in Singapore: From consumer insights to intervention co‐design

open access: yesPeople and Nature, EarlyView.
Abstract The illegal and unsustainable wildlife trade is a key driver of biodiversity loss, and reducing consumer demand is recognised as a critical step in addressing it. However, studies understanding the drivers of wildlife product consumption and identifying effective strategies to reduce it remain very limited.
Xiaotong Cai   +5 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao   +3 more
wiley   +1 more source

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