Results 111 to 120 of about 433,567 (330)

Nephroprotective Potential of Olea europaea Leaf Extract Against Combined Noise and Toluene‐Induced Oxidative and Histopathological Renal Injuries in Wistar Rats

Chemistry &Biodiversity, EarlyView.
ABSTRACT Noise and toluene are environmental stressors that induce oxidative stress and inflammation, contributing to renal dysfunction. This study evaluated the protective effects of Olea europaea leaf extract (OeLE; 40 mg/kg/day) against combined noise‐ and toluene‐induced nephrotoxicity in Wistar rats.
Takoua Ben Attia, Mabrouk Horchani, Mariem Salhi, Zeineb Dhifallah, Meriem Ksentini, Hichem Ben Jannet, Abada Mhamdi   +6 more
wiley   +1 more source

PP 2.12 – 00153 eCD4-Ig-DNA Decreased HIV Reservoir and Delayed Viral Rebound Through Fc Mediated Functions in BLT Humanized Mice

Journal of Virus Eradication, 2022
Z. Yuan, M. Purwar, S. Adeniji, Z. Xu, G. Zu, C. Hart, A. Kulkarni, M. Abdel-Mohsen, D. Weiner, L. Montaner   +9 more
doaj   +1 more source

Preclinical Immunogenicity and Efficacy Studies for Therapeutic Vaccines for Human Papillomavirus-Type-16-Associated Cancer

Vaccines
The objective of this study was to conduct preclinical immunogenicity and efficacy studies with several therapeutic vaccines for human papillomavirus (HPV)-16-associated cancers expressing the early antigens E5, E6, and E7 with or without E2.
Mohsen Mohammadi, Amara Saha, Wynetta Giles-Davis, Zhiquan Xiang, Mikhail Novikov, Mohadeseh Hasanpourghadi, Hildegund C. J. Ertl   +6 more
doaj   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]

, 2017
Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali, Borse, Vikrant, Dhukhwa, Asmita, FH Al Aameri, Raheem, Ghosh, Sumana, Kaur, Tejbeer, Lowy, Michelle, Mukherjea, Debashree, Ramkumar, Vickram, Rybak, Leonard P, Sheehan, Kelly, Sheth, Sandeep, Tupal, Srinivasan   +12 more
core   +2 more sources

Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

Chemistry – A European Journal, EarlyView.
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M. Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A. Rey   +9 more
wiley   +1 more source

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

, 2021
Liang Yin, Mingxue Zhang, Tiangeng He
openalex   +1 more source

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source

The Telomeric Response to Viral Infection

Viruses, 2017
The ends of linear genomes, whether viral or cellular, can elicit potent DNA damage and innate immune signals. DNA viruses entering the nucleus share many features with telomeres in their ability to either suppress or co-opt these pathways.
Zhuo Wang, Zhong Deng, Steve Tutton, Paul M. Lieberman   +3 more
doaj   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source