Results 211 to 220 of about 437,935 (290)

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Age-dependent remodelling of arterial chemoafferent innervation in hypertension. [PDF]

Cardiovasc Res
Pauza AG, Felippe I, de Laat I, Gold O, Shen X, Paton JFR.   +5 more
europepmc   +1 more source

Efek Jus Buah Naga Super Merah (Hylocereus costaricensis) dan Simvastatin terhadap Kadar Kolesterol Total Darah dan Bobot Badan Tikus Jantan Galur Wistar Hiperkolesterolemia

, 2014
Fauziyyah Karimah, Sadiah Achmad, R. Rizky Suganda Prawiradilaga   +2 more
openalex   +1 more source

АНТИОКСИДАТИВНИ МЕТАБОЛИЗАМ ПАЦОВА СОЈА WISTAR ИНФИЦИРАНИХ БАКТЕРИЈОМ ESCHERICHIA COLI У РАЗЛИЧИТОМ ПОСТАПЛИКАТИВНОМ ПЕРИОДУ

, 2017
Jaснa Фришчић, Maja Maнojлoвић, Свjeтлaнa Лoлић, Рaдoслaв Дeкић, Биљaнa Кукaвицa   +4 more
openalex   +2 more sources

Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats [PDF]

, 2018
Kelly Oriakhi, Patrick Uadia, Ikechi Gerald Eze   +2 more
openalex   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Docosahexaenoic Acid Consumption Early in Life Improves Immune Dysfunction in High-Fat Diet-Fed Wistar Rats in a Sex-Specific Manner. [PDF]

Mol Nutr Food Res
Wang R, Goruk S, Chan CB, Field CJ.
europepmc   +1 more source

Gambaran Histopatologik Hati Tikus Wistar yang Diberikan Sari Buah Naga Merah (Hylocereus polyrhisus) dan Parasetamol

, 2018
Maurin Wowor, Lily Loho, Poppy M. Lintong   +2 more
openalex   +2 more sources

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, EarlyView.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source