Results 251 to 260 of about 584,417 (340)

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Introduction Odanacatib (ODN), a cathepsin K inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued.
Natália dos Santos Sanches, Caroline Liberato Marchiolli, Lara Cristina Cunha Cervantes, Maria Cristina Ruiz Voms Stein, Sara Alves Berton, Estéfany Lopes Lemes do Prado, Carina Kampleitner, Francisley Ávila Souza, Roberta Okamoto, Reinhard Gruber, Idelmo Rangel Garcia Júnior   +10 more
wiley   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

<i>Etlingera Elatior</i> Inflorescence Extract Mitigates Acute Gastric Ulcers by Suppressing the Expression of Inducible Nitric Oxide Synthase in Ethanol-Induced Wistar Rats. [PDF]

J Exp Pharmacol
Prayoga DK, Aulifa DL, Budiman A, Levita J, Jiranusornkul S.   +4 more
europepmc   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Three-dimensional quantitative evaluation of hypertension-induced aortic fibre remodelling based on multiphoton microscopy: a cross-age perspective. [PDF]

R Soc Open Sci
Wang N, Zhang R, Zhao A, Yu J, Gao Y, Sun X, Chen W, Xiao N, Xiang F, Zheng W, Lin Z, Li H.   +11 more
europepmc   +1 more source

n‐3 PUFAs docosahexaenoic acid and eicosapentaenoic acid are effective natural pro‐resolution ingredients for topical skin applications

International Journal of Cosmetic Science, EarlyView.
Skin encounters many challenges that lead to an inflammatory response. Resolution of this inflammation is needed to return the skin to a healthy state. A review of the role of topical n‐3 PUFAs, particularly DHA and EPA, in resolving skin inflammation and promoting skin health is presented.
John Nip, Kevin Hermanson, Jian‐ming Lee   +2 more
wiley   +1 more source

Protective role of baicalin against methylparaben-induced reproductive toxicity: Insights into hormonal and enzymatic regulation. [PDF]

Toxicol Rep
Akaahan DI, Agu AU, Anyanwu NC, Orjiako VO, Anyanwu GE.   +4 more
europepmc   +1 more source

Yerba Mate (Ilex paraguariensis A. St.‐Hil.) Reduces Oxidative Stress and Bone Resorption in Apical Periodontitis

International Endodontic Journal, EarlyView.
ABSTRACT Aim Apical periodontitis (AP) is a highly prevalent chronic inflammatory disease that can exert systemic effects by releasing biochemical mediators that initiate and regulate the immune response. Yerba Mate (Ilex paraguariensis, YM), a popular plant broadly consumed in South America, is rich in biologically active compounds known for their ...
Carolina Sayuri Wajima, Carolina de Barros Morais Cardoso, Caroline Anselmi, Renan Dal‐Fabbro, Murilo Catelani Ferraz, Cristiane Cantiga da Silva, Paulo César Ciarlini, Edilson Ervolino, Marco Cícero Bottino, Luciano Tavares Angelo Cintra   +9 more
wiley   +1 more source