Results 311 to 320 of about 392,814 (345)

Genotoxicity of nimesulide in Wistar rats

Drug and Chemical Toxicology, 2013
It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Subas Chandra Parija, Debojyoti Borkotoky, Sushen Kumar Panda, Gyana R. sahoo   +3 more
openaire   +2 more sources

METABOLISM OF MYOSMINE IN WISTAR RATS

Drug Metabolism and Disposition, 2005
The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Stefan Tyroller, Elmar Richter, Wolfgang Zwickenpflug   +2 more
openaire   +3 more sources

Spontaneous Immunoglomerulonephritis in Wistar Rats

Pathology - Research and Practice, 1980
A strain of rats bred at the Nuclear Study Center of Mol (C.E.N.) develops a nephropathy characterized by granular deposition of immunoglobulin and complement in the renal glomeruli and tubules. We have attempted to specify the complement activation pathways (classical or alternate) in this disease by looking for their initial components (C1q, C3 and ...
Angela Fridman-Manduzio, E.H. Betz, J. Salmon   +2 more
openaire   +3 more sources

Crocin reduced acrylamide-induced neurotoxicity in Wistar rat through inhibition of oxidative stress

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms
S. Mehri, K. Abnous, Alireza Khooei, S. Mousavi, Vahideh Motamed Shariaty, H. Hosseinzadeh   +5 more
semanticscholar   +1 more source

When is a Wistar a Wistar? Behavioral profiling of outbred Wistar rats from five different suppliers using the MCSF test

Applied Animal Behaviour Science, 2011
The same strain of rats purchased from different suppliers may exhibit behavioral differences that could give rise to variability and deficient repeatability. We have previously demonstrated that outbred Wistar rats from different suppliers display striking differences in voluntary alcohol intake.
Åsa Hävermark, Sara Palm, Erika Roman, Bengt J. Meyerson, Ingrid Nylander   +4 more
openaire   +2 more sources

A supernumerary forelimb in a Wistar rat

Laboratory Animals, 1987
A fifth limb, quite independent of the others, was found in a pup born in our colony of Wistar rats. The malformation is described.
openaire   +3 more sources

Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats.

Clinica Terapeutica, 2014
OBJECTIVE In the present study, the nephroprotective and curative effects of aqueous extract of AV on gentamicin-induced tubular toxicity in male Wistar rats were investigated.
A. Baradaran, Hamid Nasri, M. Nematbakhsh, M. Rafieian-kopaei   +3 more
semanticscholar   +1 more source

Intra uterine survival and growth of Wistar and Wistar × Brown Norway rat embryos

Theriogenology, 1985
Embryos of the Wistar strain and its F(1) cross (Wistar females mated with Brown Norway males) of rats were transferred nonsurgically to 48 Wistar, 17 F(1) cross and 20 Wistar-Imamichi recipients. The two types of embryos were transferred together to each recipient to compare the viability of the embryos. Pregnancy rate was 78.8% (67 85 ). The survival
J. Nagai, S. Watanabe, S. Sugawara, J. Kobayashi   +3 more
openaire   +3 more sources

22Na+ and 86Rb+ Transport in Vascular Smooth Muscle of SHR, Wistar Kyoto, and Wistar Rats

Journal of Cardiovascular Pharmacology, 1988
To gain further insight into differences in cellular Na+ and K+ regulation between the spontaneously hypertensive rat (SHR), Wistar Kyoto (WKY), and American Wistar (W) rats, 22Na+ and 86Rb+ washouts were performed under steady-state conditions in cultured vascular smooth muscle cells from the three rat strains.
Thomas N. Denny, Satoru Kuriyama, Abraham Aviv   +2 more
openaire   +3 more sources

Spontaneous Neoplasms in Control Wistar Rats

Toxicological Sciences, 1994
Neoplastic data on 1370 control Wistar rats from 10 carcinogenicity bioassays done between 1980 and 1990 were reviewed. Mean percentage survival at 104 weeks was 58% for males and 59% for females. A total of 1857 neoplasms were diagnosed in 466 (68%) male and 582 (85%) female rats; 1390 were benign and 467 were malignant (12% with metastasis).
James Poteracki, Kathleen M. Walsh
openaire   +3 more sources