The Rhesus Factor and Disease Prevention [PDF]
, 2004 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004. ©The Trustee of the Wellcome Trust, London, 2004. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated ...
Christie, DA, Tansey, EM, Zallen, DT
core
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Population-based Research in South Wales: The MRC Pneumoconiosis Research Unit and the MRC Epidemiology Unit [PDF]
, 2002 ©The Trustee of the Wellcome Trust, London, 2002. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2002. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated ...
Ness, AR, Reynolds, LA, Tansey, EM
core
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
The underground rail road : a record of facts, authentic narratives, letters, &c., narrating the hardships, hair-breadth escapes, and death struggles of the slaves in their efforts for freedom, as related by themselves and others or witnessed by the author : together with sketches of some of the largest stockholders and most liberal aiders and advisers of the road [PDF]
, 1872 William N. Still
openalex +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Quantifying mixed-state quantum entanglement by optimal entanglement witness
, 2012 We develop an approach of quantifying entanglement in mixed quantum states by the optimal entanglement witness operator. We identify the convex set of mixed states for which a single witness provides the exact value of an entanglement measure, and show ...
H.-S. Sim +3 more
core +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source