Results 121 to 130 of about 1,587,176 (292)

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Soil formation in marine sediments and beach deposits of southern Norway: investigations of soil chronosequences in the Oslofjord region

Revista Mexicana de Ciencias Geológicas, 2018
We investigated the development of Albeluvisols and Podzols with time in southern Norway. The Vestfold region at the western shore of the Oslofjord was chosen because it is characterized by continuous glacio-isostatic uplift for the last 12,000 years ...
Isabelle Schülli-Maurer, Daniela Sauer, Karl Stahr, Ragnhild Sperstad, Rolf Sørensen   +4 more
doaj  

Per‐ and polyfluoroalkyl substances and hand osteoarthritis: data from the Osteoarthritis Initiative

Arthritis &Rheumatology, Accepted Article.
Objective To explore whether biological levels of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS – reflecting the overall effect and accounting for correlations among each PFAS – relate to incident hand osteoarthritis (HOA) and progression.
Jeffrey B. Driban, Lisa B. Rokoff, Bing Lu, Timothy E. McAlindon, Charles B. Eaton, Mary B. Roberts, Diana Mathes, Colleen Lestician, Zhijin Carrie Xu, Zhihua Tina Fan, Shawn P. O'Leary, Ida K. Haugen, Jérémie Sellam, Alice Courties, Abby F. Fleisch   +14 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Commissioning an Inexpensive Off‐The‐Shelf Spectrograph for Radial‐Velocity Studies

Astronomische Nachrichten, EarlyView.
ABSTRACT We present a way to set up an inexpensive out of the shelf spectrograph at a local observatory. Stability and resolution of the spectrograph are high enough for radial velocity determination of binary stars or determination of stellar characteristics. Even some exoplanets might be detectable via the radial velocity method.
Lukas Stock, Andreas Schrimpf
wiley   +1 more source

Bilingualism Enhances Metalinguistic Awareness in Autism: Extending the Two‐Dimensional Grammaticality Judgment Task

Autism Research, EarlyView.
ABSTRACT Bilingualism has been associated with enhanced metalinguistic awareness (MA), the ability to reflect upon language. However, findings remain mixed, and little is known about how proficiency in the most proficient (L1) and second‐best language (L2) contribute to MA, especially in children with autism spectrum disorder (ASD), who often present ...
Pauline Wolfer, Franziska Baumeister, Stephanie Durrleman   +2 more
wiley   +1 more source

System failure? Exploring the interplay of fear of failure, competition, cooperation and sense of belonging in education in England and Flanders

British Educational Research Journal, EarlyView.
Abstract Fear of failure is damaging in a host of ways yet is rife in many schools. Drawing on self‐worth theory, we explore whether fear of academic failure is higher in education systems with features that increase students' experiences of competition. To do this, we compare two very different education systems: England, where, for instance, national
Carolyn Jackson, Mieke Van Houtte
wiley   +1 more source

Is there space for dyslexia in high‐attainment educational environments? Evidence from the Millennium Cohort Study into attainment grouping in English primary schools

British Educational Research Journal, EarlyView.
Abstract Attainment grouping is an important policy issue and is increasingly practiced in UK primary schools, with researchers presenting contrasting stances on the impact to pupils' attainment and academic self‐concept. This original research statistically analyses the Millennium Cohort Study (MCS) data (N = 3510) and explores: (i) whether dyslexic ...
Esther Alice Outram
wiley   +1 more source

wolf

, 2023
wolf explores the timbral similarities between bass clarinet and very low sub tones. The timbral variation is explored via notated choreography, where the movement of the clarinet changes the frequency of the modular, which sends two low oscillator tones into a pair of subwoofer speakers.
openaire   +1 more source

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source