Results 81 to 90 of about 11,069,135 (290)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On Exposure Definition and Temporal Interpretation in the Reported Association Between Number of Pregnancies and Rheumatoid Arthritis [Response to Letter]

International Journal of Women's Health
Wenjie Sheng, Zhengguang Hu, Zhaokai Ma, Qinwen Feng, Nianmei Chen Department of Women’s Health, Shanghai Putuo Maternity and Infant Health Hospital, Shanghai, 200062, People’s Republic of ChinaCorrespondence: Nianmei Chen, Department
Sheng W, Hu Z, Ma Z, Feng Q, Chen N
doaj  

Evidence of differential effects of vitamin D receptor variants on epithelial ovarian cancer risk by predicted vitamin D status

Frontiers in Oncology, 2014
Introduction: Experimental studies suggest vitamin D inhibits ovarian carcinogenesis. Yet, epidemiologic studies of ovarian cancer risk and lifestyle correlates of vitamin D status, plasma 25-hydroxyvitamin D [25(OH)D], or vitamin D receptor (VDR ...
Jennifer ePrescott, Jennifer ePrescott, Kimberly A. Bertrand, Kimberly A. Bertrand, Brett M. Reid, Jennifer ePermuth-Wey, Immaculata eDe Vivo, Immaculata eDe Vivo, Immaculata eDe Vivo, Daniel W. Cramer, Daniel W. Cramer, Kathryn L. Terry, Kathryn L. Terry, Shelley S. Tworoger, Shelley S. Tworoger   +14 more
doaj   +1 more source

The challenges of midlife women: themes from the Seattle midlife Women’s health study

Women's Midlife Health, 2018
BackgroundMidlife, the period of the lifespan between younger and older adulthood, has been described as a period of transition in women’s lives. Investigators studying midlife have focused on women 40 to 65 years of age, who typically experience ...
A. Thomas, E. Mitchell, N. Woods
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Women's Health Initiative [PDF]

Science, 2006
![Figure][1] Earlier this year, after 12 years, 7.5 million forms, and 1 million clinic visits, the Women's Health Initiative (WHI), a major 15-year research program of the U.S. National Institutes of Health (NIH), announced its research findings about women and chronic diseases. It indicated that certain interventions to treat cardiovascular disease,
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epidemiological Profile of Syphilis in Pregnant Women in the city of Macaé Rio de Janeiro

Clinical and Biomedical Research, 2021
Introduction:The gestational and congenital syphilis are diseases that can be prevented. Practices routinely carried out in prenatal care are effective for the prevention of cases.
Adail Orrith Liborio Neto, Juliane de Freitas Santos, Carlos Alexandre Ribeiro Goulart   +2 more
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

High‐Dose Hormone Replacement Therapy Improved Embryo Transfer Outcomes in a Woman With 21‐Hydroxylase Deficiency Who Had Persistently High Serum Progesterone Levels: A Case Report and Literature Review

Clinical Case Reports
Women with 21‐hydroxylase deficiency have reduced fertility because of excessive production of adrenal androgen and progesterone, which can inhibit folliculogenesis, disturb the normal gonadotropin secretion pattern and development of the endometrium ...
Yuri Mizusawa, Hiroaki Shibahara, Masahide Shiotani   +2 more
doaj   +1 more source