Results 61 to 70 of about 479,526 (268)

The Dynamic Impact of Periodic Review on Women’s Rights [PDF]

, 2018
Human rights treaty bodies have been frequently criticized as useless and the regime’s self-reporting procedure widely viewed as a whitewash. Yet very little research explores what, if any, influence this periodic review process has on governments ...
Creamer, Cosette D., Simmons, Beth A.
core   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Income requirements in family reunification regimes [PDF]

, 2016
The Human Rights of Migrant Women in International and European Law shows the existence of a gender bias in European norms – at both EU and domestic level – regulating migrant women’s family life and employment.
Staiano, Fulvia
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Embracing Partnership for Social Transformation and the Realization of Human Rights: A Pathway to Ending Female Genital Mutilation, Marginalization of Women in Political Leadership, and Other Harmful Practices Amongst the Abagusii of Kenya

Interdisciplinary Journal of Partnership Studies, 2020
Utilizing the Abagusii community of Southwestern Kenya as a case study, the author explores how patriarchy, a social system that is embedded in a domination social configuration (Eisler, 2007), is fertile ground for several practices which violate girls’
Kerubo Abuya
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

‘Woman, but not Human’

Civilistica.com, 2013
This article examines the implications of widowhood practices for the enjoyment of women’s fundamental rights and freedoms in Nigeria. The article discusses the effects of socio-cultural and legal structures of Nigeria for gender equality. It argues that
Ebenezer Durojaye
doaj  

Investigating the Moral, Social, Economic, Cultural and Political Rights of Women and the Family in the Human Rights Charter (Islamic Scholarship with Secular Science in the Eyes of the Woman) [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
The purpose of this study is to review and criticize the human rights charter in the social, economic, cultural, and political component of women and family in relation to the religion of Islam.
Zahra Mosavi, Tayebeh Mahrosadeh, Mohammad Seyfi   +2 more
doaj  

The lady vanishes: what's missing from the stem cell debate [PDF]

, 2006
Most opponents of somatic cell nuclear transfer and embryonic stem cell technologies base their arguments on the twin assertions that the embryo is either a human being or a potential human being, and that it is wrong to destroy a human being or ...
A. Fagot-Largeault, A. Jacobs, A. M. Honore, A. Ryan, C. A. MacKinnon, C. McLeod, C. Pateman, C. Waldby, CCNE (Comite Consultatif National d’Ethique), CCNE (Comite Consultatif National d’Ethique) and Nationaler Ethikrat. Opinion no. 77, D. B. Resnik, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, Donna L. Dickenson, E. Marshall, G. A. Cohen, G. Meilander, G. W. F. Hegel, HUGO (Human Genome Organisation) Ethics Council, I. Schneider, J. Boyle, J. E. Penner, J. E. Penner, J. L. Schroeder, J. Locke, J. Mahoney, J. McHale, J. Montgomery, J. W. Harris, J. Waldron, K. E. Ferguson, K. Momberger, L. Brace, M. J. Radin, R. Macklin, R. R Faden, Royal College of Obstetricians and Gynaecologists (RCOG) Ethics Committee, S. Dodds, S. E. Lanzendorf, S. Holland, S. Holm, T. Grey, T. Harrison, T. Murray, W. E. Connolly, W. S. Hwang   +50 more
core   +2 more sources

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source