Results 201 to 210 of about 4,890,725 (324)

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

open access: yesAdvanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo   +40 more
wiley   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon   +10 more
wiley   +1 more source

Knowledge and perception of labor rights violations among postpartum women in three Brazilian maternity hospitals: a cross-sectional study. [PDF]

open access: yesBMC Pregnancy Childbirth
Munezero A   +10 more
europepmc   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

open access: yesAdvanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren   +9 more
wiley   +1 more source

Data‐Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties

open access: yesAdvanced Science, EarlyView.
A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong   +7 more
wiley   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

open access: yesAdvanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang   +12 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

open access: yesAdvanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy