Results 41 to 50 of about 115,635,683 (250)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Frontiers in Soil Science, 2023 IntroductionIn the world, 33% of soils are degraded, and 2.9 million people are affected by land degradation, with problems associated with food security, conflicts over natural resources, and migration with different impacts on men or women.
Jhoana Hernández +14 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2014 Conferència “Women & STEM” a càrrec de la Linda Sax. Actualment, és la directora del Programa Student Affairs Graduate a UCLA, i les seves línees d’investigació han estat: Dona i STEM (Science, Technology, Engineering & Mathematics), les diferències de ...
core +1 more source
eLife, 2022 Background: When researchers’ careers are disrupted by life events – such as illness or childbirth – they often need to take extended time off. This creates a gap in their research output that can reduce their chances of winning funding.
Adrian Barnett +3 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Analyzing the existing programs on promoting women scientists in chemistry
Chemistry Teacher InternationalGender imbalance in science has been well documented. Possible explanations include a lack of systematic strategies or policies to support women in science in general and chemistry in particular.
Fung Fun Man +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Women in Supramolecular Chemistry [PDF]
, 2022 EPDF and EPUB available Open Access under CC-BY-NC-ND licence. Drawing on research carried out by the Women in Supramolecular Chemistry (WISC) network, this book sets out the extent to which women working in STEM face inequality and discrimination.
von Krbrek, Larissa K.S. +12 more
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Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source