Results 91 to 100 of about 597,190 (357)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

Nombres aniquilados: publicaciones femeninas y lectores

open access: yesCriticón, 2015
During the Sixteenth century some women writers’ paratexts described their readers. It was possible because of the previous dissemination of the texts and the controversy they originated.
Nieves Baranda Leturio
doaj   +1 more source

Critique [of What Shall I Give My Children? The role of the Mentor in Gloria Naylor\u27s The Women of Brewster Place and Paule Marshall\u27s Praisesong for the Widow by Linda Wells] [PDF]

open access: yes, 1990
In her article \u27What Shall I Give My Children?\u27: The Role of the Mentor in Gloria Naylor\u27s The Women of Brewster Place and Paule Marshall\u27s Praisesong for the Widow, Wells focuses upon the woman\u27s role as mentor in various works of modem
Stutman, Suzanne
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Entre burlas y veras: las estrategias reivindicativas de Manuela Tomasa Sánchez de Oreja y Francisca de Osorio, escritoras de almanaques

open access: yesCuadernos de Ilustración y Romanticismo, 2019
The genre of almanacs or astrological forecasts, so in vogue in Spain in the 18th century, was also cultivated by women, such as Manuela Sánchez de Oreja, «la Gran Piscatora Aureliense», and Francisca de Osorio, «la Musaraña del Pindo».
María Dolores Gimeno Puyol
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao   +10 more
wiley   +1 more source

А. P. Chekhov’ Reception in Russian “Women’s Prose” of the End of 20th - the Beginning of 21st Century

open access: yesНаучный диалог, 2017
The problem of literary traditions continuity, namely the influence of the literary heritage of A. P. Chekhov on contemporary Russian women’s prose is examined.
S. Zhang
doaj   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini   +7 more
wiley   +1 more source

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