Results 61 to 70 of about 22,164 (263)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

'Si no fuere tu hija ilustre': Women Writers’ Social Status in Early Modern Spain

open access: yesCuadernos de Historia Moderna, 2019
The numbers of women writers of the early modern Spain currently identified have risen to over five hundred, with their writings catalogued and systematized by the Spanish data base Biblioteca de Escritoras Españolas (BIESES).
Anne J. Cruz
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Entre burlas y veras: las estrategias reivindicativas de Manuela Tomasa Sánchez de Oreja y Francisca de Osorio, escritoras de almanaques

open access: yesCuadernos de Ilustración y Romanticismo, 2019
The genre of almanacs or astrological forecasts, so in vogue in Spain in the 18th century, was also cultivated by women, such as Manuela Sánchez de Oreja, «la Gran Piscatora Aureliense», and Francisca de Osorio, «la Musaraña del Pindo».
María Dolores Gimeno Puyol
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Neki arhivski primeri neiskorišćenog kulturnog kapitala

open access: yesPoznańskie Studia Slawistyczne, 2016
Archives are important places for researching and reconstructing the past, they lead to discoveries, and they can refute dominant stereotypes. Despite that fact, Serbian feminist scholars have neglected archival research of women writers.
Svetlana Tomić
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Nombres aniquilados: publicaciones femeninas y lectores

open access: yesCriticón, 2015
During the Sixteenth century some women writers’ paratexts described their readers. It was possible because of the previous dissemination of the texts and the controversy they originated.
Nieves Baranda Leturio
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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