Results 121 to 130 of about 23,580,719 (284)
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
February Oversight Report [PDF]
, 2010 February report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the state of commercial real estate and the impact of real estate losses to the stability of the ...
United States. Congressional Oversight Panel.
core
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Numerical Study of I-Joists with Wood-Based Corrugated Panel Web
BioResourcesOriented strand board (OSB) panels are widely used as the best web solution for wooden I-joists. Many previous studies have focused on testing various new web materials, but few have examined the contribution of other web shapes to the I-joists' behavior.
Abdessamad Jiloul +2 more
doaj
Evaluation of wheat straw for the development of bio-based panels
Discover MaterialsThis study explores the potential of wheat straw (Triticum aestivum) for producing structural panels suitable for use in the building industry. The research was motivated by the large volume of agricultural waste that is commonly underutilized or burned,
Arun Kuttoor Vasudevan +5 more
doaj +1 more source
Advanced Science, EarlyView.A latent diffusion‐based framework is proposed for designing functionally graded metamaterials with perfect connectivity. By integrating vector‐quantized latent representations with mechanistic guidance, the framework enables accurate inverse design toward target elastic properties.
Jongbin Yu, Dosung Lee, Namjung Kim
wiley +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source