A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun +13 more
wiley +1 more source
Manufacturing and characterization of innovative lightweight wooden furniture from polystyrene core wood sandwich panels. [PDF]
Kelleci O +4 more
europepmc +1 more source
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini +19 more
wiley +1 more source
Wood-Based Oriented Object Deposition for Programmable Mechanical and 3D Fluidic Control. [PDF]
Kim Y, Kang D, Shin S.
europepmc +1 more source
Evaluation of drug options for epithelial ovarian cancer (EOC) treatment using the analytical hierarchy process improves decision-making transparency. [PDF]
Ghorbani H +7 more
europepmc +1 more source
Expert Elicitation on Exposure to Tick Bites and Tick-Borne Encephalitis Risk in Occupational and Recreational Forest Activities. [PDF]
Saegerman C +8 more
europepmc +1 more source
Extended influenza seasons in Australia and New Zealand in 2025 due to the emergence of influenza A(H3N2) subclade K viruses. [PDF]
Dapat C +13 more
europepmc +1 more source
Reversible lignin stabilization in traditional aqueous pulping conditions using boric acid
Luterbacher J +10 more
europepmc +1 more source

