Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Chlorine (Cl) and hydrogen chloride (HCl) solubility in hydrous silicate melts: implications for volcanic gas composition. [PDF]
Rusiecka MK, Wood BJ.
europepmc +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Correction: Berezowski et al. Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study. <i>Cancers</i> 2025, <i>17</i>, 2588. [PDF]
Berezowski B +13 more
europepmc +1 more source
A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing +26 more
wiley +1 more source
Dual-Confinement Strategy Enables Highly Efficient Oxygen Reduction with Fe-N<sub>5</sub> Electrocatalysts. [PDF]
Li S +6 more
europepmc +1 more source
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis +32 more
wiley +1 more source
Use of the Child Opportunity Index in Adolescent and Young Adult Health Research. [PDF]
Luke MJ, Wood SM, Beck AF.
europepmc +1 more source

