Results 41 to 50 of about 129,628 (262)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Particle size distribution of Japanese cedar chip converted from boards using a disc chipper and its relationships with disc rotation speed and board feed speed

Journal of Wood Science
The effects of disc chipper rotation speed and raw material feed speed on the particle size distribution of wood chips produced were investigated to develop an efficient technique for producing ideal sized chips for the stable operation of combined heat ...
Yosuke Matsuda, Yukari Matsumura, Takashi Yanagida, Kiyohiko Fujimoto   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Moisture Behaviour of Glulam Made from Mixed Species

Applied Sciences
The objective of this study was to determine the moisture content gradient over the thickness of glued laminated timber structures, manufactured as five-layer structures from two different species.
Roxana Gall, Mihai Ispas, Octavia Zeleniuc, Bogdan Bedelean, Sergiu Georgescu, Mihaela Campean   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Investigating the spatio-temporal risk of in-ground fungal wood decay over Europe using the 5th European reanalysis (ERA5-Land)

European Journal of Remote Sensing
The spatio-temporal heterogeneity of in-ground wood decay risk is important to service life planning of timber components. To achieve a desired service life in years related to a component’s expected performance, means accurately matching the durability ...
Philip B. van Niekerk, Brendan N. Marais, Gry Alfredsen, Christian Brischke   +3 more
doaj   +1 more source

Utilization of pomegranate tree pruning in the core layer of particleboard produced from Eucalyptus camedulensis wood [PDF]

تحقیقات علوم چوب و کاغذ ایران, 2013
The objective of this study was to investigate utilization of pomegranate pruning  residues as the core layer of the three layer particleboard. The percentage of the pomegranate residues varied as 100, 65 and 35% in the core layer of the eucalypt ...
Abolfazl Kargarfard, Amir Nourbakhsh, Fardad Golbabaei   +2 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source