Results 61 to 70 of about 4,492,542 (312)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The thesis work in the doctoral fomation process

Revista MENDIVE, 2020
In the process of doctoral formation, the researching skills formation is essential, one of the ways that the doctoral committees can use to impact on it, are the thesis workshops, thus the objective of the present article is proposingactions to perform ...
Maricela María González Pérez, Tomás Castillo Estrella   +1 more
doaj  

The organizational culture in the aging process of educational work

Administração: Ensino e Pesquisa, 2020
Population aging is one of the most significant phenomena in the 21st century and this phenomenon has important far-reaching impacts on society and organizations.
Flávia Obara Kai, Mariane Lemos Lourenço, Camilla Fernandes   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Interdisciplinarity in work process at a Psychosocial Attention Center [PDF]

Revista Brasileira em Promoção da Saúde, 2010
Objective: To analyze the work process of mental health professionals from a Psychosocial Attention Center (CAPS), from the knowledge and the practices applied in the production of care and its interface with user’s demands and the service offering ...
Maria Salete Bessa Jorge, Fabergna Dianny de Almeida Sales, Antonio Germane Alves Pinto, José Jackson Coelho Sampaio   +3 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

MODEL SIMULASI KINERJA PRODUKSI TEH UNTUK MINIMISASI WORK-IN-PROCESS

Jurnal Optimasi Sistem Industri, 2010
Simulasi komputer adalah salah satu cara yang digunakan untuk menganalisis suatu sistem dengan cara memodelkannya menggunakan software komputer. Dengan menggunakan simulasi kita dapat melihat secara langsung proses kerja dari sistem.
Agus Wibowo, Demi Ramadian
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source