Results 61 to 70 of about 757,606 (279)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

EU WORK-LIFE INTEGRATION: LEGISLATIVE DEVELOPMENTS [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2023
The objective of this paper is to analyze the evolution of work-life balance legislation in the European Union (EU), from its adoption in 2019 to its mandatory implementation among member states in 2022 or later, prompted by EU infringement procedures.
ANDREI DALINA-MARIA
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

A Qualitative Exploration of Work-Life Balance: Experiences of Millennial Married Women Workers [PDF]

open access: yesInternational Journal of Management, Accounting and Economics, 2020
This qualitative study examined Work-Life Balance (WLB) experiences of millennial married women workers in Bekasi area using a phenomenological study.
L Liswandi
doaj  

PENGARUH WORK-LIFE BALANCE DAN MOTIVASI TERHADAP KINERJA KARYAWAN [PDF]

open access: yes
Employee performance is essential in achieving organizational goals. Work-life balance and motivation need to be considered in supporting employee performance. The purpose of this research is to find out whether there is an influence of work-life balance
Azhar, Muhammad Rizky Zuhair
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

PENGARUH WORK LIFE BALANCE TERHADAP KEPUASAN KERJA DENGAN STRES KERJA SEBAGAI VARIABEL INTERVENING (Studi Pada PT. BPD Kalimantan Tengah Cabang Buntok) [PDF]

open access: yes
This research aims to determine how the work life balance, job satisfaction, and work Stress, the effect of the work life balance on job satisfaction, the effect of work life balance on work Stress, and the effect of work Stress on job satisfaction, and ...
Riyana, Nindi Dwi
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Gender Gap in the Career Success of University Graduates: Effects of Work-Related Values

open access: yesSwiss Journal of Sociology, 2020
The article deals with the unequal career outcomes between women and men. The data from the graduate survey are used to investigate the effect of work-related values on career success. The Oaxaca-Blinder decomposition determines which factors can explain
Zimmermann Barbara
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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