Results 91 to 100 of about 3,218,349 (283)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

PENGARUH WORK LIFE BALANCE TERHADAP KEPUASAN KERJA DENGAN STRES KERJA SEBAGAI VARIABEL INTERVENING (Studi Pada PT. BPD Kalimantan Tengah Cabang Buntok) [PDF]

open access: yes
This research aims to determine how the work life balance, job satisfaction, and work Stress, the effect of the work life balance on job satisfaction, the effect of work life balance on work Stress, and the effect of work Stress on job satisfaction, and ...
Riyana, Nindi Dwi
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Information system quality in work-life balance

open access: yesKnowledge Management & E-Learning: An International Journal, 2016
This paper aims to look for the role information systems quality may play in work-life balance among Malaysian ICT employees. The results of this study will be useful in the development of new tools and technologies that are focused on ISQ dimensions ...
Sharmini Gopinathan, Murali Raman
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Job insecurity, work passion, and work–life balance in diverse work arrangements

open access: yesSA Journal of Industrial Psychology
Orientation: The coronavirus disease 2019 (COVID-19) pandemic shifted work settings, revealing gaps in current literature on how work arrangements affect employee experiences and well-being.
Chantell Ribas   +3 more
doaj   +1 more source

Traditional vs. secular values and work-life well being across Europe [PDF]

open access: yes, 2007
This paper examines how culture, defined in our analysis by reference to traditional versus secular values, affects the work-life balance across Europe.
Georgellis, Y, Lange, T
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

PENGARUH WORK-LIFE BALANCE DAN MOTIVASI TERHADAP KINERJA KARYAWAN [PDF]

open access: yes
Employee performance is essential in achieving organizational goals. Work-life balance and motivation need to be considered in supporting employee performance. The purpose of this research is to find out whether there is an influence of work-life balance
Azhar, Muhammad Rizky Zuhair
core  

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