Results 191 to 200 of about 723,255 (243)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Work-life balance as a mediator between perceived stress and work withdrawal behavior among critical care nurses in China: a multicenter cross-sectional study. [PDF]

Front Public Health
Li J, Wang J, Li S, Dai D, Xu Y.
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Author's Reply Regarding "Work-life Balance in Pediatric Orthopaediatrics: The Role of the Leaders". [PDF]

J Pediatr Soc North Am
Frick S, Glavin R, Franklin C, Waters P.
europepmc   +1 more source

Anaesthesia provider perspectives on well-being, work-life balance, and burnout prevention: a qualitative exploration. [PDF]

Br J Anaesth
Gasciauskaite G, Munzert SA, Seelandt J, Gisselbaek M, Tscholl DW, Nöthiger CB, Roche TR.   +6 more
europepmc   +1 more source

Demographic and occupational factors associated with work-life balance among physician assistants/associates: a cross-sectional study. [PDF]

BMJ Open
Bruza-Augatis M, Nash T, Puckett K, Kozikowski A, Morton-Rias D, Goodman J.   +5 more
europepmc   +1 more source

Letter to the Editor Regarding "Work-Life Balance in Pediatric Orthopaedics: The Role of the Leaders". [PDF]

J Pediatr Soc North Am
Trionfo A.
europepmc   +1 more source

The relationship of flexible working arrangements on work-family conflict, work-life balance and organizational commitment: a systematic review and meta-analysis. [PDF]

BMC Psychol
Çivilidağ A, Durmaz Ş.
europepmc   +1 more source

Work-life balance, job satisfaction, and burnout among nurses in Jordan: A cross-sectional study. [PDF]

PLoS One
Abuhammad S, Abuhammad S, Alzoubi KH, Al-Azzam S, Karasneh R, Masadeh MM, Alameddine M.   +6 more
europepmc   +1 more source