Results 61 to 70 of about 1,148,706 (260)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Balancing and Conflict Between Work and Family Life of Sandwiched Caregivers: A Scoping Review
Safety and Health at WorkThe aim of this scoping review was to advance our understanding of the balancing and conflict between work and family life experienced by sandwiched caregivers.
Ayumi Honda +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Jurnal ASET (Akuntansi Riset), 2020 This research examines whether work-family conflict (both work-interfering family and family interfering work) among auditors in public accounting firms affects their job performance and whether the effect is mediated by work-life balance.
Rini Rini +2 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
When Conflict be a Trigger of Depression: between Job and Life Satisfaction
Jurnal Dinamika Manajemen, 2018 The objective of this study is to investigate the effect of work-family conflict and family-work conflict on depression behavior mediated by job satisfaction and life satisfaction.
Sulimah Sulimah, Nury Ariani Wulansari
doaj +1 more source
An Empirical Study on the Effect of Work/Life Commitment to Work-Life Conflict
Physics Procedia, 2012 AbstractThis study examined the relation between work and life orientation and work interfere with personal life or personal life interfere with work of employees in China. Cluster analysis results showed that there are four profiles of orientation: work orientation, life orientation, integration and disengagement orientation.
Ma, Li, Yin, Jie-lin
openaire +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Salāmat-i kār-i Īrān, 2018 Background and aims: The aim of this present study was to examine the effectiveness of work- life conflict management model on life satisfaction and work engagement of male employees.
salman zarei +3 more
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