Results 141 to 150 of about 42,525,269 (408)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Does Gamification Work? -- A Literature Review of Empirical Studies on Gamification

open access: yesHawaii International Conference on System Sciences, 2014
Juho Hamari, Jonna Koivisto, Harri Sarsa
semanticscholar   +1 more source

Work statistics in stochastically driven systems [PDF]

open access: gold, 2014
Gatien Verley   +2 more
openalex   +1 more source

ADULT PREFERENCES OF SOLIDS-ENRICHED MILK [PDF]

open access: yes
Food Consumption/Nutrition/Food Safety,
Criner, George K.   +2 more
core   +1 more source

Control Over Work Hours and Alternative Work Schedules [PDF]

open access: yes, 2001
[Excerpt] Alternative work schedules encompass work hours that do not necessarily fall inside the perimeters of the traditional and often rigid 8-hour workday or 40-hour workweek.
AFL-CIO Working Women’s Department   +1 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Appreciative supervision in social work. New opportunities for changing the social work practice [PDF]

open access: yes
The practice of social work focuses mainly on solving problems, on reducing dysfunctions, on diminishing deficiencies etc. More often then not, allocating resources for providing problem-centred social services does not solve the problems for which the ...
Stefan COJOCARU
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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