Results 151 to 160 of about 40,520,256 (406)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
String and other Forms of Strand; Basketry‐, Woven bag‐, and Net‐work. By Walter E. Roth [PDF]
, 1901 O. T. Mason
openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
An Address on the Life and Scientific Work of Albrecht Von Graefe [PDF]
, 1886 Donders
openalex +1 more source
Preliminary evaluation of ERTS-1 for determining numbers and distribution of prairie ponds and lakes [PDF]
ERTS-1 and aircraft multispectral data collected over a North Dakota test site during July 1972, are compared to evaluate the capability of the satellite sensors to detect numbers and distribution of prairie ponds and lakes. Recognition maps using ERTS-1,
Gilmer, D. S. +2 more
core +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
A Diagnostic Unit for Practitioners and its First Five Years' Work [PDF]
, 1951 John H. Hunt
openalex +1 more source
On the interaction of small and large eddies in two dimensional turbulent flows [PDF]
Some results concerning the interaction of small and large eddies to two dimensional turbulent flows are presented. It is shown that the amplitude of small structures decays exponentially to a small value, and from this is inferred a simplified ...
ate work., Foias, C.
core +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Ciencia y Enfermería, 2009 Este estudio descriptivo correlacional fue realizado a través de una recopilación retrospectiva con 796 trabajadores de enfermería de un hospital público brasileño y buscó identificar la existencia de una relación entre la enseñanza recibida sobre el ...
Adriane Corrêa Jansen +1 more
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