Results 251 to 260 of about 42,525,269 (408)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Lots of Shiny Junk at the Art Dump: The Sick and Unwilling Curator

Parse Journal, 2019
Lina Džuverović, Irene Revell
doaj  

Occupational and Environmental Determinants of Musculoskeletal Disorders Among Nurses in Conflict-Affected Gaza Hospitals. [PDF]

Ann Glob Health
Eleiwa AZ, Khadoura KJ.
europepmc   +1 more source

The Global Crisis and The Turkish Economy [PDF]

Ferhan Salman, Sukru Binay
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Artists as Enterprise Incorporating as Forms of Organising Agencies

Parse Journal, 2019
Ashley Lee Wong
doaj  

Moderating effect of social support in the relationship between perceived work overload and patient safety behaviours among nursing interns in Nigeria. [PDF]

Front Health Serv
Balogun AG, Onyencho VC, Oduaran CA.
europepmc   +1 more source

Inflation Dynamics and Reaction Function in High-inflation Environment : An Implication for Turkey [PDF]

Runchana Pongsaparn
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source