Results 41 to 50 of about 40,520,256 (406)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Клінічна хірургія, 2019 Резолюція експертної ради щодо питання покращення прогнозу лікування пацієнтів із захворюванням периферичних артерій. 1 лютого 2019 р.
Work Group
doaj
Low intensity surface fire instigates movement by Calosoma frigidum (Coleoptera, Carabidae)
ZooKeys, 2011 The genus Calosoma (Coleoptera: Carabidae) is a group of large, sometimes ornate beetles, which often voraciously attack caterpillars. Many studies have reported Calosoma beetles being highly conspicuous during defoliator outbreaks.
Jenna Jacobs +3 more
doaj +1 more source
Aging, work and technology: application driver as a laboral possibility for the 50+ population
Cadernos Brasileiros de Terapia Ocupacional, 2021 Introduction: The demographic transition in Brazil has led individuals over 50 years old to remain involved in labor activities for a longer time. Concomitantly, there is the appearance of the “gig” economy, characterized by the provision of services ...
Luana de Barros +1 more
doaj +1 more source
, 2019 When working on fractions, one can use the Vedic sutra Transpose and Apply to solve faster and with much ease. From here, one can then extend the application of this sutra in fractions and use it in problems involved in the real-world. One of those problems is Work Problems; that is, if person 1 can do the work in time t1, and person 2 can do the work ...
openaire +2 more sources
Current Biology, 1992 The term working memory refers to a brain system that provides temporary storage and manipulation of the information necessary for such complex cognitive tasks as language comprehension, learning, and reasoning. This definition has evolved from the concept of a unitary short-term memory system.
openaire +4 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Gene Therapy for Cardiovascular Disease [PDF]
, 2003 The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H. +3 more
core +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source