Results 241 to 250 of about 13,693,389 (293)
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
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2022
The available data leaves no doubt that compulsive overworking is a genuine problem related to significant harm. Thus far, most cases were recognized in relation to the official diagnosis of anankastia/obsessive–compulsive personality disorder (OCPD). However, while this personality domain may be a risk factor, the available evidence suggests that work
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The available data leaves no doubt that compulsive overworking is a genuine problem related to significant harm. Thus far, most cases were recognized in relation to the official diagnosis of anankastia/obsessive–compulsive personality disorder (OCPD). However, while this personality domain may be a risk factor, the available evidence suggests that work
+4 more sources
Non-drug Addiction: Addiction to Work
2022Work addiction refers to the problem of compulsive overworking, conceptualized as an addictive disorder. It has substantial epidemiological significance due to high prevalence rates (ranging from about 7% to 20% depending on the country); harm to self and others, particularly family, children, co-workers, and recipients of work; and related economic ...
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2006
Abstract In recent years there has been growing interest amongst clinical psychologists in working with those who experience a variety of addictions. This chapter outlines the role of psychologists within addiction services and the nature of the individuals they work with.
Shamil Wanigaratne +2 more
openaire +1 more source
Abstract In recent years there has been growing interest amongst clinical psychologists in working with those who experience a variety of addictions. This chapter outlines the role of psychologists within addiction services and the nature of the individuals they work with.
Shamil Wanigaratne +2 more
openaire +1 more source
Employee Assistance Quarterly, 1997
Summary This paper examines the literature on work addiction, including recent definitions of the construct and the psychometric properties of the first instrument to measure work addiction. The growing anecdotal and empirical literature are discussed in terms of the impact of work addiction on family functioning with practical implications for EAP ...
openaire +1 more source
Summary This paper examines the literature on work addiction, including recent definitions of the construct and the psychometric properties of the first instrument to measure work addiction. The growing anecdotal and empirical literature are discussed in terms of the impact of work addiction on family functioning with practical implications for EAP ...
openaire +1 more source
Development of a work addiction scale
Scandinavian Journal of Psychology, 2012Andreassen, C. S., Griffiths, M. D., Hetland, J. & Pallesen, S. (2012). Development of a work addiction scale. Scandinavian Journal of Psychology 53, 265–272.Research into excessive work has gained increasing attention over the last 20 years. Terms such as “workaholism,”“work addiction” and “excessive work” have been used interchangeably. Given the
Cecilie Schou, Andreassen +3 more
openaire +2 more sources