Results 91 to 100 of about 6,631,713 (291)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
From single-shot towards general work extraction in a quantum thermodynamic framework
New Journal of Physics, 2015 This paper considers work extraction from a quantum system to a work storage system (or weight) following Horodecki and Oppenheim (2013 Nat. Commun. http://dx.doi.org/10.1038/ncomms3059 4 http://dx.doi.org/10.1038/ncomms3059 ). An alternative approach is
Jochen Gemmer, Janet Anders
doaj +1 more source
Paul Taylors Biocentric Ethics: A Survey of Contemporary Environmental Conflicts [PDF]
, 2019 This work is on Paul Taylors Biocentric Ethics: A Survey of Contemporary Environmental Conflicts. When we accept the concept of biocentrism there is bound to exist conflicts between interests and cultural values of humans and the well-being of nonhuman ...
Big-Alabo, Sotonye
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
"Orientation" as a Sensitizing Concept in Social Work
Journal of Comparative Social Work, 2015 Studying institutional discourses between clients and social workers could strengthen reflections on social work practices by asking: What definitions of the situation do the partners talk from?
Siv Oltedal
doaj
5 x 5: Conceptual and Technical Challenge [PDF]
, 2019 Goals for the Week to Week Project As an undergraduate student pursuing a BFA, the apotheosis of my education is to find and develop the content for my art and convey it in the form of my capstone BFA exhibition.
Castillo, Madeline
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Alienation - a long-overlooked concept of relevance to social work?
Social Work and Society, 2019 Alienation is seemingly a relevant concept in social work in so far as this concerns marginalized and vulnerable groups of people. Nevertheless, the interest in alienation theory has declined within social science as a whole, partly due to postmodern ...
Henrik Skovlund
doaj +2 more sources
Shift work sleep disorder in nurses: a concept analysis
BMC NursingAim This study seeks to elucidate the concept of shift work sleep disorder (SWSD) among nurses, thereby offering a comprehensive understanding that can inform future research and practical interventions. Methods Walker and Avant’s concept analysis method
Liangmeng Yu +3 more
doaj +1 more source