Results 111 to 120 of about 14,662,958 (352)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Seeking Peace of Mind: A Case Study Combining Ethics and Accounting [PDF]

open access: yes, 2016
The purpose of this research has been to create original work in the form of a case study that educators and accounting students can benefit from during daily exercises in accounting ethics ...
Ghahremani, Lauren
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Investigating the relationship between work values and work ethics: A South African perspective

open access: yesSA Journal of Human Resource Management, 2017
Orientation: As a result of the proliferation of unethical behaviour in the workplace, the study of work ethics has received new impetus. Research purpose: The research study sought to determine the relationship between work ethics and work values, with
Petronella Jonck   +2 more
doaj   +1 more source

A randomized trial of a lab-embedded discourse intervention to improve research ethics. [PDF]

open access: yes, 2020
We report a randomized trial of a research ethics training intervention designed to enhance ethics communication in university science and engineering laboratories, focusing specifically on authorship and data management.
Baranski, Erica N   +7 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

A Study on Impact of Work Ethics on Task Performance (Case Study: the Employees of University of Mohaghegh Ardabili) [PDF]

open access: yesپژوهش‌های مدیریت عمومی, 2013
Ethics has an innate value and work ethic is a cultural norm. Work ethics encourage people to perform their jobs properly by giving a spiritual value to their performance.
doaj   +1 more source

The Effect of Personality Traits on Employee Job Satisfaction with Moderating Role of Islamic Work Ethics

open access: yesJournal of Asian Finance, Economics and Business, 2019
Personality factors and ethical values are considered as vital element in social and professional life. This present research aims to explore the relationship between Personality and Job Satisfaction.
R. Jalal   +2 more
semanticscholar   +1 more source

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