Results 111 to 120 of about 2,119,607 (304)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The virtue of Bonhoeffer's ethics: a study of Dietrich Bonhoeffer's Ethics in relation to virtue ethics [PDF]

, 2009
Jennifer Moberly, 'The Virtue of Bonhoeffer's Ethics: A Study of Dietrich Bonhoeffer's Ethics in Relation to Virtue Ethics' (PhD, 2009) This study first explores the prima facie reasons for rejecting the possibility of seeing a close relationship ...
MOBERLY, JENNIFER,LYNNE
core  

Ethics and social networking sites: A disclosive analysis of Facebook

, 2010
Paper has been accepted for publication in Information, Technology and People.Purpose: This paper provides insights into the moral values embodied by a popular social networking site (SNS), Facebook.
Light, B, McGrath, K, Light, BA, Ben Light, Kathy McGrath, Light, Ben, McGrath, Kathy   +6 more
core   +1 more source

Pengaruh Komunikasi Organisasi, Karakteristik Individu, Kemampuan Kerja dan Etika Kerja Terhadap Prestasi Kerja Karyawan

Jurnal Akutansi Manajemen Ekonomi Kewirausahaan
The purpose of this study was to determine the effect of organizational communication, individual characteristics, work ability and work ethic on employee performance at PT. Nusantara Plantation IV.
Haya Fachira, Ezzah Nahrisah, Arasy Ayu Setiamy   +2 more
doaj   +1 more source

Does Organizational Cronyism Lead to Lower Employee Performance? Examining the Mediating Role of Employee Engagement and Moderating Role of Islamic Work Ethics. [PDF]

Front Psychol, 2020
Shaheen S, Zulfiqar S, Saleem S, Shehazadi G.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Ethics of Responsibility

, 2010
This agenda setting text explores a broad range of value perspectives and their impact on and contribution to social work thinking on ethics. Including new perspectives, such as Islam, and drawing on international contributors, this is essential reading ...
Tascon, Sonia, Tascon, Sonia (R19065)
core  

Determinasi Career Readiness, Personal Branding, dan Etika Kerja terhadap Job Search Intention Mahasiswa Generasi Digital

Jurnal Manajemen Stratejik dan Simulasi Bisnis
This study aims to examine the determinants of job search intention in final-year college students through the roles of career readiness, personal branding, and work ethic. Tight competition in the job market demands that college graduates possess career
Masyitoh Nadia, Ikhsan Maksum
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The mediating role of work ethics in the relationship of job enthusiasm with primary school teachers' innovative behavior

فصلنامه زن و جامعه
Received: Revised: Accepted: Abstract Introduction: The present study was conducted with the aim of explaining the mediating role of work ethics in the relationship between job enthusiasm and innovative behavior of primary school teachers in Shiraz ...
Abbas Gholtash
doaj