Results 141 to 150 of about 14,662,958 (352)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Analisis Faktor yang Mempengaruhi Etos Kerja Penyuluh Agama Kristen

Dunamis: Jurnal Teologi dan Pendidikan Kristiani
. Christian Religion Extension Workers face great challenges in carrying out their duties, so they require a high work ethics to maximize their performance.
Tiur Imeldawati, Hermanda Ihut Tua Simamora, Dame Taruli, Elsina Sihombing, Winda Manalu   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The mediating role of work ethics in the relationship of job enthusiasm with primary school teachers' innovative behavior

فصلنامه زن و جامعه
Received: Revised: Accepted: Abstract Introduction: The present study was conducted with the aim of explaining the mediating role of work ethics in the relationship between job enthusiasm and innovative behavior of primary school teachers in Shiraz ...
Abbas Gholtash
doaj  

Aligning faith and function: the role of religious human resource practices and work ethics in shaping employee job engagement

Cogent Psychology
Comprehensive human resource practices are increasingly recognized as strategic mechanisms for enhancing job engagement. Religiously oriented approaches offer distinct advantages, as they align with employees’ intrinsic beliefs and motivations, thereby ...
Lokot Zein Nasution, Mohammad Mulyadi, Akhmad Junaidi, Johnny W. Situmorang, A.M. Wibowo, Sahat Aditua Fandhitya Silalahi, Hotnier Sipahutar, Amsal Amsal, Agustinus Hartopo, Asrori Asrori, Endro Winarno   +10 more
doaj   +1 more source

Investigating the Effect of Work Ethics on the Positive Organizational Behavior Based on Fred Luthans’s Model (CHOSE) (Case study: Group22, Shahreza Artillery) [PDF]

مدیریت بهره وری, 2013
Due to managerial weakness and the use of non-human models to solve human issues, one of the problems that employees are faced with today is the problem of work ethics.
Alireza shirvani, Farzad Sisakhti
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The association between work ethics and attitudes towards organizational changes among the administrative, financial and support employees of general teaching hospitals.

Journal of Medical Ethics and History of Medicine, 2015
In order to achieve success in today's competitive world, organizations should adapt to environmental changes. On the other hand, managers should have a set of values and ethical guidelines for their administrative and organizational functions.
Ramin Ravangard, Zahra Sajjadnia, Abdosaleh Jafari, Najme Shahsavan, Jamshid Bahmaie, Mohammadkarim Bahadori   +5 more
doaj  

Exploring Discourse Ethics for Tourism Transformation [PDF]

, 2018
The 'critical turn' in tourism studies is defined as a research perspective that explores social transfor- mation in and through tourism by facing the negative impact of strategic-instrumental rationality on this activity. This work explores the features
Lopez-González, Jose L.
core   +3 more sources