Results 181 to 190 of about 22,567,699 (313)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Looking Into the Black Box: A Survey of the Matching Function [PDF]

open access: yes
We survey the microfoundations, empirical evidence and estimation issues underlying the aggregate matching function. Several microeconomic matching mechanisms have been suggested in the literature with some successes but none is generally accepted as ...
Christopher A. Pissarides   +1 more
core  

β-Mercaptoethanol-Enabled Long-Term Stability and Work Function Tuning of MXene. [PDF]

open access: yesSmall Sci, 2022
Jing H   +7 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Participation in decision-making by social work middle managers in fulfilling the administrative function

open access: yes, 1995
Thesis (M.A.) -- University of Stellenbosch, 1995.ENGLISH ABSTRACT: An exploratory study relating to participation in decision-making by social work middle managers in performing the administrative function was undertaken.
Blekkenhorst, Noelene
core  

2D KBr/Graphene Heterostructures-Influence on Work Function and Friction. [PDF]

open access: yesNanomaterials (Basel), 2022
Liu Z   +6 more
europepmc   +1 more source

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