Results 191 to 200 of about 16,416,515 (385)

Performance management process changes on the work identity of employees during COVID-19

, 2023
Kelley Clayton, Roslyn T. de Braine
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Developing an effective process for securing learning support for participants in work-based learning [PDF]

, 2006
Gentleman, Sylvia
core  

Nothing About Us Without Us: On Publishing the Patient Voice. [PDF]

Med Care
Tjia J.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A risk communication intervention aimed at enhancing help-seeking behavior and reducing stress symptoms in healthcare workers: a pilot study with a process evaluation. [PDF]

BMC Psychol
Emal LM, Tamminga SJ, Beumer A, Kezic S, Timmermans DR, Schaafsma FG, van der Molen HF.   +6 more
europepmc   +1 more source

Using the emancipatory values of social work as a guide to the investigation: What processes and principles represent good practice with people on community treatment orders?

, 2009
Lisa Brophy
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Youth work in schools : an investigation of youth work, as a process of informal learning, in formal settings [PDF]

, 2008
Morgan, Pat, Morgan, Tony, O'Kelly, Brian   +2 more
core  

Fluctuation theorems for autonomous work. [PDF]

Proc Natl Acad Sci U S A
Jarzynski C, Deffner S, Rahav S.
europepmc   +1 more source