Results 291 to 300 of about 16,416,515 (385)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Cultural Competency in Research: A Practical Framework for Use by Researchers, Policymakers, Community Leads and Others When Working With People From Diverse Groups. [PDF]

Health Expect
Stepanova E, Cooper M, Robinson-Barella A, Harris V, Rance A, Husband A, Wright D, Lorencatto F, Tolley C, Tovey W, Wong G, Cowie D, Parker K, Crayton E, Nazar H.   +14 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

AI-Assisted Composite Etch Model for MPT. [PDF]

Micromachines (Basel)
Gong Y, Zhao F, Sima D, Li W, Guo Y, Hu C, Zhang S.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Navigating the Gap: An Examination of Funder Rhetoric and Reality Regarding Community-Research Partnerships. [PDF]

Drug Alcohol Rev
Russell DM, Morrison E, Grebely J, Treloar C, Gobeil J, Doumany J, Stowe MJ, Dietze P, Seear K, Taylor N, Ritter A.   +10 more
europepmc   +1 more source

Individual Placement and Support and Participatory Workplace Intervention for people with work disabilities - experiences of job coaches. [PDF]

BMC Public Health
Oude Geerdink E, Maarleveld JM, van Kempen H, van Weeghel J, Anema JR, Huysmans MA.   +5 more
europepmc   +1 more source

Analysis of Roll Pass Wear in the Railway Rail Rolling Process. [PDF]

Materials (Basel)
Szota P, Mróz S, Stefanik A, Zygmunt T, Bołda M.   +4 more
europepmc   +1 more source

Polymer Melt Stability Monitoring in Injection Moulding Using LSTM-Based Time-Series Models. [PDF]

Polymers (Basel)
Costa P, Mendes SP, Loureiro P.
europepmc   +1 more source

Precarization of teaching work in private higher education: a case study on the processes of productive restructuring and flexibilization [PDF]

Kátia Rodrigues Montalvão PAIAS
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