Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smallpox eradication surveillance : global medium-term programme, program 13.1
, 1983 World Health Organization seventh general programme of work covering the period 1984-1989."SME/MTP/83.16 ...
World Health Organization
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Developing a short standard questionnaire for assessing work organization hazards: the Healthy Work Survey (HWS). [PDF]
Ann Occup Environ Med, 2023 Choi B, Seo Y.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Fortified Construction Techniques in al-Ṭagr al-Awsaṯ, 8th–13th Centuries
Arts, 2018 Spanish Islamic military architecture shows an attempt at the systematization of works, techniques, and defensive elements, commencing in the era of the Umayyad Emirate and Caliphate up to the North African Empires (Almoravids and Almohads). This article
Ignacio Javier Gil Crespo +2 more
doaj +1 more source
Work Organization Factors Associated With Nurses' Stress, Sleep, and Performance: A Pre-pandemic Analysis. [PDF]
J Nurs Regul, 2022 Stimpfel AW +3 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Global Public HealthClimate-related extreme weather events (EWE) affect sexual and reproductive health and rights (SRHR) outcomes through complex and multi-level pathways. These include institutional-level effects on health systems, such as damaged health infrastructure and
Manjulaa Narasimhan +3 more
doaj +1 more source
The Healthy Work Survey: A Standardized Questionnaire for the Assessment of Workplace Psychosocial Hazards and Work Organization in the United States. [PDF]
J Occup Environ Med, 2023 Dobson M +3 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source