Results 161 to 170 of about 17,105,617 (263)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Organización del trabajo e innovación: Un estudio comparativo entre ramas productivas argentinas

open access: yesEconomía Teoría y Práctica, 2011
El objetivo principal del presente artículo es analizar las características que adopta la organización del trabajo en un conjunto de empresas pertenecientes a diferentes ramas productivas argentinas y su vinculación con los procesos de innovación.
Analía Erbes   +2 more
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

The Changing organization of work and the safety and health of working people : knowledge gaps and research directions

open access: yes
Organizational practices have changed dramatically in recent years. To compete more effectively, many companies have restructured themselves and downsized their workforces, increased their reliance on nontraditional employment practices that depend on ...

core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Work Organisation Form Efficiency Conditions in Sewing Rooms

open access: yes
The objective of the research is to determine/find work organization form alternatives for the progressive bundle system and teamwork in modular manufacturing, as well as to determine the conditions of their implementation and maintenance in a sewing ...
Ziemele, Inese   +2 more
core  

The impact of the work organization on individuals' psychological well-being. [PDF]

open access: yesFront Public Health
Riccardi E   +6 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

East African Freshwater Fisheries Research Organization Annual Report 1974

open access: yes, 1974
The Annual report covers activities of the organization during the reporting period. It explains the scientific work carried out by the organization, the establishment of the Lake Victoria Fisheries Commission and the African Journal of Tropical ...

core  

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