Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Personalized Surgical Tactics for an Adult Patient with Mitral Insufficiency and Dextrocardia with Situs Inversus Totalis. [PDF]
Kozlov BN +6 more
europepmc +1 more source
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Teaching early-career researchers how to respond to peer reviewers. [PDF]
Kalkhoven E, Kluijtmans M.
europepmc +1 more source
Gender differences in submission behavior exacerbate publication disparities in elite journals. [PDF]
Ni C +5 more
europepmc +1 more source
Evaluating automated or artificial intelligence search tools for evidence synthesis. [PDF]
Featherstone R.
europepmc +1 more source
Nurturing others neglecting self: A qualitative study on work-life balance among nurse educators at a Gauteng nursing education institution. [PDF]
Mathebula L, Mathevula RF, Ramalepa TN.
europepmc +1 more source
Workload perception and job satisfaction among Lebanese practicing dietitians: A cross-sectional study by employment location. [PDF]
Daher M, Serhan C, Chedid R, Serhan M.
europepmc +1 more source

