Results 81 to 90 of about 23,609,372 (344)

Increased autophagy signaling but not proteasome activity in human skeletal muscle after prolonged low‐intensity exercise with negative energy balance

Physiological Reports, 2017
Little is known about the molecular regulation of skeletal muscle protein turnover during exercise in field conditions where energy is intake inadequate. Here, 17 male and 7 female soldiers performed an 8 days long field‐based military operation.
Marcus Moberg, Gina Hendo, Madelene Jakobsson, C. Mikael Mattsson, Elin Ekblom‐Bak, Mikael Flockhart, Marjan Pontén, Karin Söderlund, Björn Ekblom   +8 more
doaj   +1 more source

Novel work-based learning courses in analytical sciences

, 2010
The Open University (OU) is well known for the delivery of world class distance education. From 2010, the OU offers a new Foundation Degree in Analytical Sciences, developed to enhance the skills base of the workforce in analytical laboratories.
Velasco, Maria, Williams, Ruth
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effects of individual resilience intervention on indigenous people who experienced Typhoon Morkot in Taiwan

Kaohsiung Journal of Medical Sciences, 2012
In 2009, Typhoon Morakot struck Taiwan and caused serious harm to the indigenous peoples living in the southern mountainous regions. The objective of this study is to examine the effects of and the factors involved in individual resilience intervention ...
Su-Fen Cheng, Chi-Wei Cheng, Wen-Chung Hsieh, Meng-Chun Chi, Szu-Ju Lin, Yi-Ting Liao   +5 more
doaj   +1 more source

Poster: Researchers Say the Darndest Things: Using Semi-structured Interviews to Uncover the Unique Information Behaviors of Basic Sciences Researchers in an Academic Health Center [PDF]

, 2011
Laura discusses the work she and her colleagues did in a qualitative study of semi-structured interviews examining the unique, information-seeking characteristics of basic sciences researchers.
Haines, Laura L
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Exposure frequencies of single adverse childhood experiences and their association with psychological distress: evidence from a cohort study among emerging Swiss adults

BMC Public Health
Background Adverse childhood experiences (ACE) are significant transdiagnostic risk factors for impaired psychosocial functioning throughout life.
Simon Marmet, Salome I.R. Bötschi, Neela Vetsch, Lina Stallmann, Jeannette Brodbeck   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Hikikomori among young adults: examining the protective function of psychological resilience

BMC Psychology
Background Hikikomori is a phenomenon of social isolation characterized by an individual’s intentional and prolonged withdrawal from social life, and it has increasingly drawn global scholarly attention. In Turkey, the limited number of empirical studies
Taner Artan, Ecem Çakin, Rumeysa Dinçer, Aydın Olcay Özkan   +3 more
doaj   +1 more source

At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1 [PDF]

, 2014
Funding AS was supported by a Cancer Research UK PhD studentship and ORSAS. SK is supported by a Scottish Universities Life Sciences Alliance PhD studentship.
Donaldson, Anne D., Kedziora, Sylwia, Sridhar, Akila   +2 more
core   +4 more sources